Obtaining of C-C coupling products in reactions with C-nucleophiles using acid-base catalysis is simple way of azines functionalization

Project: Award Project


Activation of the C-C coupling processes can be accomplished by obtaining an azine cation or by generating an anion of a nucleophile in the reaction medium. The formation of a cation by acid catalysis in the reactions of azines with nucleophilic agents is perspective, since it opens access to the products of C-C coupling, excluding the use of quaternary alkyl salts of the starting heterocyclic compounds.
Homogeneous catalysis is universal for the practical realization of transformations with a large number of nucleophiles.
The main task of this project is to investigate the feasibility of applying acid-base catalysis to benzoannelated 1,4- and 1,3-diazines for the reactions of nucleophilic C-C coupling. Our purpose is to develop methods obtaining of C-C coupling products for benzoannelated monoazines.
In the course of realization of the C-C coupling reactions, it is proposed to investigate the competitive processes of azine transformation under the action of nucleophilic agents.
Analysis of the main and side processes will give us possibility to optimize the yield of the target products
Effective start/end date01/01/201831/12/2019


  • RFFI
  • Mira Research Division