A group of original 1,3,4-thiadiazines, containing cycloalkylamine residues in position 2 of 1,3,4-thiadiazine ring, were tested for antiaggregation activity in vitro. All the studied compounds reduced platelet aggregation induced by ADP and arachidonic acid. The most active inhibitors of ADP-induced platelet aggregation were L-52, L-59 compounds with hexamethylenimine residues and L-58 compound with morfoline residue in position 2 of 1,3,4-thiadiazine ring. Compound L-36 — 1,3,4-thiadiazine with thiomorfoline residue — proved to be the most active antiaggregant in platelet aggregation induced by arachidonic acid.
|Translated title of the contribution||Experimental study of antiaggregation effect of 2-cycloalkyl-amino-5-phenyl-1,3,4-5H(C 2H 5)-thiadiazines in vitro|
|Number of pages||4|
|Journal||ГЕМАТОЛОГИЯ И ТРАНСФУЗИОЛОГИЯ|
|Publication status||Published - 2013|