АНТИАГРЕГАЦИОННОЕ ДЕЙСТВИЕ 2-ЦИКЛОАЛКИЛАМИНО-5-ФЕНИЛ-1,3,4-6Н (С 2 Н 5)-ТИАДИАЗИНОВ В ЭКСПЕРИМЕНТАХ IN VITRO

Translated title of the contribution: Experimental study of antiaggregation effect of 2-cycloalkyl-amino-5-phenyl-1,3,4-5H(C 2H 5)-thiadiazines in vitro

Юлия Сергеевна Логвинова, Татьяна Михайловна Васильева, Владимир Александрович Макаров, Олег Николаевич Чупахин, Лариса Петровна Сидорова, Наталья Михайловна Перова, Владимир Леонидович Русинов

Research output: Contribution to journalArticlepeer-review

Abstract

A group of original 1,3,4-thiadiazines, containing cycloalkylamine residues in position 2 of 1,3,4-thiadiazine ring, were tested for antiaggregation activity in vitro. All the studied compounds reduced platelet aggregation induced by ADP and arachidonic acid. The most active inhibitors of ADP-induced platelet aggregation were L-52, L-59 compounds with hexamethylenimine residues and L-58 compound with morfoline residue in position 2 of 1,3,4-thiadiazine ring. Compound L-36 — 1,3,4-thiadiazine with thiomorfoline residue — proved to be the most active antiaggregant in platelet aggregation induced by arachidonic acid.
Translated title of the contributionExperimental study of antiaggregation effect of 2-cycloalkyl-amino-5-phenyl-1,3,4-5H(C 2H 5)-thiadiazines in vitro
Original languageRussian
Pages (from-to)37-40
Number of pages4
JournalГЕМАТОЛОГИЯ И ТРАНСФУЗИОЛОГИЯ
Volume58
Issue number2
Publication statusPublished - 2013

GRNTI

  • 34.45.00

Level of Research Output

  • VAK List

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