Влияние температуры на активность и проводимость р ианодинового рецептора сердечной клетки: математическое моделирование

Translated title of the contribution: Temperature Effect on the Cardiac Ryanodine Receptor Gating and Conductance: Mathematical Modelling

Research output: Contribution to journalArticle

Abstract

"The temperature effed; on the cardiac ryanodine receptor fundion has been studied within the e1ectron-conformationa1 model. It is shown that simple e1ectron-conformationa1 model with the Arrhenius like temperature dependence of “internal” and “externa1” fictions and spetifi; “thermosensitivity” of the tunnelling “open о dose” transitions can provide both qualitative and quantitative desaiption of the temperature effeds for isolated ryanodine receptors. The potential of the model was illustrated by exp1aining the experimenta1 data on the temperature dependence of sheep’s isolated cardiac ryanodine receptor gating and conductance (R. Sitsapesan et al., J. Physiol. (1991), 434, 469)."
Translated title of the contributionTemperature Effect on the Cardiac Ryanodine Receptor Gating and Conductance: Mathematical Modelling
Original languageRussian
Pages (from-to)726-735
Number of pages10
JournalBiophysics
Volume61
Issue number4
Publication statusPublished - 2016

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