ИЗМЕНЕНИЯ ИЗОФОРМ ГЕМОГЛОБИНА В ПЕРИФЕРИЧЕСКОЙ КРОВИ КРЫС ПРИ ЭКСПЕРИМЕНТАЛЬНОЙ ПОСТГЕМОРРАГИЧЕСКОЙ АНЕМИИ

Translated title of the contribution: HEMOGLOBIN ISOFORMS IN PERIPHERAL BLOOD IN THE RAT MODEL OF BLOOD LOSS ANEMIA

Research output: Contribution to journalArticlepeer-review

Abstract

Six hemoglobin isoforms were identified in the peripheral blood of male Wistar rats by electrophoresis in polyacrylamide gel. Erythrocytes can be separated into 6 fractions by fractional centrifugation; the fractions differ in the level of reticulocytes and cells with fetal hemoglobin. The cells of each fraction contain one light isoform and one heavier isoform, and their combination is specific to each fraction. Changes in the hemoglobin heterogeneity in the whole blood in case of blood loss are associated with changes in physical and chemical properties of circulating erythrocytes, as well as with the formation of various cell populations resulting from activated erythropoiesis.
Translated title of the contributionHEMOGLOBIN ISOFORMS IN PERIPHERAL BLOOD IN THE RAT MODEL OF BLOOD LOSS ANEMIA
Original languageRussian
Pages (from-to)424-428
Number of pages5
JournalБюллетень экспериментальной биологии и медицины
Volume171
Issue number4
DOIs
Publication statusPublished - 2021

GRNTI

  • 76.00.00 MEDICINE AND HEALTH CARE

Level of Research Output

  • VAK List

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