КОНСЕНСУСНЫЙ ПРОГНОЗ, НАПРАВЛЕННЫЙ СИНТЕЗ И ОПРЕДЕЛЕНИЕ АНТИГЛИКИРУЮЩЕЙ И АНТИАГРЕГАНТНОЙ АКТИВНОСТЕЙ 3,6-ДИЗАМЕЩЕННЫХ 1,2,4,5-ТЕТРАЗИНОВ

Translated title of the contribution: In silico consensus activity prediction, rational synthesis, and evaluation of antiglycation and antiplatelet activities of 3,6-disubstituted 1,2,4,5-tetrazines

Р. И. Ишметова, Д. А. Бабков, А. Ф. Кучерявенок, В. А. Бабкова, В. С. Сиротенко, Н. К. Игнатенко, С. Г. Толщина, П. М. Васильев, Г. Л. Русинов, А. А. Спасов

Research output: Contribution to journalArticle

Abstract

According to the in silico consensus activity prediction, a series of 3,6-disubstituted 1,2,4,5-tetrazines were synthesized as promising inhibitors of the Maillard reaction. In addition to the studies of antiglycation activity, a comparative in vitro evaluation of the effect of the synthesized compounds on the ADP-induced rabbit platelet aggregation model was carried out. Compounds with antiglycation and antiplatelet activities significantly higher than that of the reference drugs, aminoguanidine and acetylsalicylic acid, were revealed.

Translated title of the contributionIn silico consensus activity prediction, rational synthesis, and evaluation of antiglycation and antiplatelet activities of 3,6-disubstituted 1,2,4,5-tetrazines
Original languageRussian
Pages (from-to)768-773
Number of pages6
JournalИзвестия Академии наук. Серия химическая
Publication statusPublished - 2020

Keywords

  • 3,6-disubstituted 1,2,4,5-tetrazines
  • acetyl-salicylic acid
  • aminoguanidine
  • antiglycation activity
  • antiplatelet activity
  • consensus activity prediction
  • in silico studies
  • Maillard reaction

GRNTI

  • 31.00.00 CHEMISTRY

Level of Research Output

  • VAK List

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