СРАВНИТЕЛЬНАЯ И КОМБИНИРОВАННАЯ ТОКСИЧНОСТЬ НАНОЧАСТИЦ ОКСИДОВ АЛЮМИНИЯ, ТИТАНА И КРЕМНИЯ И ЕЁ ОСЛАБЛЕНИЕ КОМПЛЕКСОМ БИОПРОТЕКТОРОВ

Translated title of the contribution: COMPARATIVE AND COMBINED TOXICITY OF ALUMINIUM, TITANIUM AND SILICON OXIDES NANOPARTICLES AND ITS ALLEVIATION WITH THE COMPLEX OF BIOPROTECTORS

И. А. Минигалиева, Б. А. Кацнельсон, Л. И. Привалова, М. П. Сутункова, В. Б. Гурвич, В. Я. Шур, Е. В. Шишкина, И. Е. Валамина, О. Г. Макеев, В. Г. Панов, А. Н. Вараксин, С. В. Клинова, С. В. Соловьева, Е. Ю. Мещерякова

Research output: Contribution to journalArticlepeer-review

Abstract

Stable suspensions of metal/metalloid oxide nanoparticles (MeO-NPs) obtained by laser ablation of 99.99% pure elemental aluminum, titanium or silicon under a layer of deionized water were used separately or in different combinations to induce subchronic intoxications in rats. To this end, MeO-NPs had been repeatedly injected intraperitoneally (i.p.) 18 times during 6 weeks before a large number of functional, biochemical and morphometric indexes for the organism’s status were measured. It was found that, in many respects, the Al2O3-NPs were the most toxic as such and the most dangerous component of the studied combinations. Mathematical modeling with the help of the Response Surface Methodology has shown that the response of the organism to a simultaneous exposure to any two of the MeO-NPs under study is characterized by all possible types of combined toxicity (additivity, subadditivity or superadditivity of unidirectional action and different variants of opposite effects) depending on which outcome this type is estimated for as well as on the levels of the effect and dose. With any third MeO-NP species acting in the background, the type of combined toxicity displayed by the other two can change significantly. Many adverse effects produced by the [Al2O3-NP+TiO2-NP+SiO2-NP]-combination, including its genotoxicity, were substantially attenuated by giving to rats per os during the entire exposure period complex of innocuous bioprotective substances.
Translated title of the contributionCOMPARATIVE AND COMBINED TOXICITY OF ALUMINIUM, TITANIUM AND SILICON OXIDES NANOPARTICLES AND ITS ALLEVIATION WITH THE COMPLEX OF BIOPROTECTORS
Original languageRussian
Pages (from-to)18-27
JournalТоксикологический вестник
Issue number2
Publication statusPublished - 2018

GRNTI

  • 34.00.00 BIOLOGY

Level of Research Output

  • VAK List

Fingerprint

Dive into the research topics of 'COMPARATIVE AND COMBINED TOXICITY OF ALUMINIUM, TITANIUM AND SILICON OXIDES NANOPARTICLES AND ITS ALLEVIATION WITH THE COMPLEX OF BIOPROTECTORS'. Together they form a unique fingerprint.

Cite this