ЭКСПЕРИМЕНТАЛЬНОЕ ИЗУЧЕНИЕ КАРДИОТОКСИЧЕСКОГО ДЕЙСТВИЯ НАНОЧАСТИЦ ОКСИДА СВИНЦА ПРИ РАЗНЫХ ПУТЯХ ПОСТУПЛЕНИЯ В ОРГАНИЗМ

Translated title of the contribution: THE EXPERIMENTAL STUDY OF CARDIOTOXIC EFFECTS OF LEAD OXIDE NANOPARTICLES BY THEIR VARIOUS ROUTES OF EXPOSURE

И. А. Минигалиева, М. П. Сутункова, Светлана Владиславовна Клинова, С. Н. Соловьева, Л. И. Привалова, Владимир Борисович Гурвич, Иван Николаевич Чернышов, Ю. В. Рябова, Т. В. Бушуева, Владимир Яковлевич Шур, Екатерина Владимировна Шишкина, Б. А. Кацнельсон

Research output: Contribution to journalArticle

Abstract

Background: Lead oxide nanoparticles are emitted in the workplace air of copper smelters. They are also a by-product in many other metallurgical industries. Objectives: Adverse health effects of lead oxide nanoparticles (PbO-NPs) were assessed in vivo using various routes of exposure with special attention paid to particle cardiotoxicity. Materials and methods: The subacute inhalation experiments were conducted on outbred female rats exposed to the generated aerosol of PbO-NPs in the concentration of 1.30 ± 0.10 mg/m3, 4 hours a day during five consecutive days, using the Nose-Only Inhalation Exposure System. The study of subchronic exposure to PbO-NPs was conducted on male rats using intraperitoneal injections made thrice a week during six weeks (18 injections in total). Conclusions: Following both types of exposure to PbO-NPs, we observed changes in toxicological indices including those specific for lead including a decrease in hemoglobin counts, an increase in blood reticulocyte counts and urine concentrations of δ-aminolevulenic acid. The subacute inhalation exposure to PbO-NPs affected electrocardiographic findings in animals (an increase in amplitudes of P and T waves) while the subchronic intraperitoneal injections decreased blood pressure and changed biochemical indices of the cardiovascular system (decreased activity of the angiotensin-converting enzyme and the concentration of endodelin-1).
Translated title of the contributionTHE EXPERIMENTAL STUDY OF CARDIOTOXIC EFFECTS OF LEAD OXIDE NANOPARTICLES BY THEIR VARIOUS ROUTES OF EXPOSURE
Original languageRussian
Pages (from-to)67-72
Number of pages6
JournalЗдоровье населения и среда обитания
Issue number9 (330)
DOIs
Publication statusPublished - 2020

GRNTI

  • 76.00.00 MEDICINE AND HEALTH CARE

Level of Research Output

  • VAK List

Fingerprint Dive into the research topics of 'THE EXPERIMENTAL STUDY OF CARDIOTOXIC EFFECTS OF LEAD OXIDE NANOPARTICLES BY THEIR VARIOUS ROUTES OF EXPOSURE'. Together they form a unique fingerprint.

Cite this