6-ТРИФТОРМЕТИЛ-2-ТИОУРАЦИЛ И ЕГО АНАЛОГИ В РЕАКЦИЯХ С (4-БРОМБУТИЛ)АЦЕТАТОМ И 2-БРОМАЦЕТОФЕНОНОМ

Translated title of the contribution: 6-Trifluoromethyl-2-thiouracil and its analogs in reactions with 4-bromobutyl acetate and 2-bromoacetophenone

Research output: Contribution to journalArticle

Abstract

The alkylation of 6-(polyfluoro)alkyl-2-thiouracils with 4-bromobutyl acetate in refluxing acetonitrile in the presence of K2CO3 proceeds regioselectively to give S,O-disubstituted pyrimidines as the major products and S,N-isomers as the minor ones, whereas the use of 2-bromoacetophenone as an alkylating agent results in the formation of the S,O-isomer. 6-Trifluoromethyl-2-thiouracil and 2-(2-oxo-2-phenylethylthio)-4-(2-oxo-2-phenylethoxy)-6-trifluoromethylpyrimidine exhibited marked tuberculostatic activity. 6-Trifluoromethyl-2-thiouracil did not exert a significant cytotoxic effect on the HeLa cell culture and human dermal fibroblasts.
Original languageRussian
Pages (from-to)1190-1195
Number of pages6
JournalИзвестия Академии наук. Серия химическая
Issue number6
Publication statusPublished - 2019

GRNTI

  • 31.00.00 CHEMISTRY

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  • VAK List

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