Multiple biological active 4-aminopyrazoles containing trifluoromethyl and their 4-nitroso-precursors: Synthesis and evaluation

Yanina V. Burgart, Natalia A. Agafonova, Evgeny V. Shchegolkov, Olga P. Krasnykh, Svetlana O. Kushch, Natalia P. Evstigneeva, Natalia A. Gerasimova, Vera V. Maslova, Galina A. Triandafilova, Sergey Yu Solodnikov, Maria V. Ulitko, Galina F. Makhaeva, Elena V. Rudakova, Sophia S. Borisevich, Natalia V. Zilberberg, Nikolai V. Kungurov, Victor I. Saloutin, Oleg N. Chupakhin

Research output: Contribution to journalArticle

1 Citation (Scopus)
Original languageEnglish
Article number112768
Number of pages17
JournalEuropean Journal of Medicinal Chemistry
Volume208
DOIs
Publication statusPublished - 15 Dec 2020

Keywords

  • 4-Hydroxyiminopyrazolines
  • Acute toxicity
  • ADME calculations
  • Analgesic activity
  • Antibacterial
  • Antimycotic
  • Antioxidant
  • Cytotoxic
  • Trifluoromethyl-containing 4-amino- and 4-nitrosopyrazoles
  • Tuberculostatic
  • ONE-POT SYNTHESIS
  • PYRAZOLE DERIVATIVES
  • FREE-RADICAL SCAVENGER
  • IDENTIFICATION
  • DISCOVERY
  • IN-VITRO
  • NITRIC-OXIDE
  • RECENT PROGRESS
  • INHIBITORS
  • EDARAVONE RADICUT

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Organic Chemistry

WoS ResearchAreas Categories

  • Chemistry, Medicinal

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