Synthesis and antituberculosis activity of novel 5-styryl-4-(hetero)aryl-pyrimidines via combination of the Pd-catalyzed Suzuki cross-coupling and S-N(H) reactions

Marionella A. Kravchenko, Egor V. Verbitskiy, Igor D. Medvinskiy, Gennady L. Rusinov, Valery N. Charushin

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)
Original languageEnglish
Pages (from-to)3118-3120
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume24
Issue number14
DOIs
Publication statusPublished - 15 Jul 2014

Fingerprint

Pyrimidines
Russia
Mycobacterium tuberculosis
Pharmaceutical Preparations
Toxicity
Hydrogen
Tuberculosis
Substitution reactions
In Vitro Techniques
5-bromopyrimidine

Keywords

  • Pyrimidine
  • Antimicobacterial
  • Tuberculosis
  • Cross-coupling
  • Nucleophilic aromatic substitution of hydrogen
  • MYCOBACTERIUM-TUBERCULOSIS
  • ANTIMYCOBACTERIAL ACTIVITY
  • ANALOGS
  • PURINES
  • AGENTS
  • DRUGS

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Electronic, Optical and Magnetic Materials

Cite this

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title = "Synthesis and antituberculosis activity of novel 5-styryl-4-(hetero)aryl-pyrimidines via combination of the Pd-catalyzed Suzuki cross-coupling and S-N(H) reactions",
keywords = "Pyrimidine, Antimicobacterial, Tuberculosis, Cross-coupling, Nucleophilic aromatic substitution of hydrogen, MYCOBACTERIUM-TUBERCULOSIS, ANTIMYCOBACTERIAL ACTIVITY, ANALOGS, PURINES, AGENTS, DRUGS",
author = "Kravchenko, {Marionella A.} and Verbitskiy, {Egor V.} and Medvinskiy, {Igor D.} and Rusinov, {Gennady L.} and Charushin, {Valery N.}",
year = "2014",
month = "7",
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language = "English",
volume = "24",
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journal = "Bioorganic and Medicinal Chemistry Letters",
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T1 - Synthesis and antituberculosis activity of novel 5-styryl-4-(hetero)aryl-pyrimidines via combination of the Pd-catalyzed Suzuki cross-coupling and S-N(H) reactions

AU - Kravchenko, Marionella A.

AU - Verbitskiy, Egor V.

AU - Medvinskiy, Igor D.

AU - Rusinov, Gennady L.

AU - Charushin, Valery N.

PY - 2014/7/15

Y1 - 2014/7/15

KW - Pyrimidine

KW - Antimicobacterial

KW - Tuberculosis

KW - Cross-coupling

KW - Nucleophilic aromatic substitution of hydrogen

KW - MYCOBACTERIUM-TUBERCULOSIS

KW - ANTIMYCOBACTERIAL ACTIVITY

KW - ANALOGS

KW - PURINES

KW - AGENTS

KW - DRUGS

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U2 - 10.1016/j.bmcl.2014.05.006

DO - 10.1016/j.bmcl.2014.05.006

M3 - Article

VL - 24

SP - 3118

EP - 3120

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 14

ER -