Synthesis, and structure-activity relationship for C(4) and/or C(5) thienyl substituted pyrimidines, as a new family of antimycobacterial compounds

Egor V. Verbitskiy, Ekaterina M. Cheprakova, Pavel A. Slepukhin, Marionella A. Kravchenko, Sergey N. Skornyakov, Gennady L. Rusinov, Oleg N. Chupakhin, Valery N. Charushin

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)
Original languageEnglish
Pages (from-to)225-234
Number of pages10
JournalEuropean Journal of Medicinal Chemistry
Volume97
DOIs
Publication statusPublished - 5 Jun 2015

Keywords

  • Pyrimidine
  • Antimicobacterial
  • Tuberculosis
  • Cross-coupling
  • Nucleophilic aromatic substitution of hydrogen
  • MYCOBACTERIUM-TUBERCULOSIS
  • ANTITUBERCULOSIS ACTIVITY
  • COUPLING REACTIONS
  • ARYL BROMIDES
  • DERIVATIVES
  • INHIBITORS
  • ANALOGS
  • S-N(H)
  • AGENTS
  • CHEMOTHERAPY

ASJC Scopus subject areas

  • Organic Chemistry
  • Drug Discovery
  • Pharmacology (medical)
  • Medicine(all)

Cite this

@article{fac00e342e2a46ef8c40118b3da57d0b,
title = "Synthesis, and structure-activity relationship for C(4) and/or C(5) thienyl substituted pyrimidines, as a new family of antimycobacterial compounds",
keywords = "Pyrimidine, Antimicobacterial, Tuberculosis, Cross-coupling, Nucleophilic aromatic substitution of hydrogen, MYCOBACTERIUM-TUBERCULOSIS, ANTITUBERCULOSIS ACTIVITY, COUPLING REACTIONS, ARYL BROMIDES, DERIVATIVES, INHIBITORS, ANALOGS, S-N(H), AGENTS, CHEMOTHERAPY",
author = "Verbitskiy, {Egor V.} and Cheprakova, {Ekaterina M.} and Slepukhin, {Pavel A.} and Kravchenko, {Marionella A.} and Skornyakov, {Sergey N.} and Rusinov, {Gennady L.} and Chupakhin, {Oleg N.} and Charushin, {Valery N.}",
year = "2015",
month = "6",
day = "5",
doi = "10.1016/j.ejmech.2015.05.007",
language = "English",
volume = "97",
pages = "225--234",
journal = "European Journal of Medicinal Chemistry",
issn = "0223-5234",
publisher = "Elsevier",

}

Synthesis, and structure-activity relationship for C(4) and/or C(5) thienyl substituted pyrimidines, as a new family of antimycobacterial compounds. / Verbitskiy, Egor V.; Cheprakova, Ekaterina M.; Slepukhin, Pavel A.; Kravchenko, Marionella A.; Skornyakov, Sergey N.; Rusinov, Gennady L.; Chupakhin, Oleg N.; Charushin, Valery N.

In: European Journal of Medicinal Chemistry, Vol. 97, 05.06.2015, p. 225-234.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Synthesis, and structure-activity relationship for C(4) and/or C(5) thienyl substituted pyrimidines, as a new family of antimycobacterial compounds

AU - Verbitskiy, Egor V.

AU - Cheprakova, Ekaterina M.

AU - Slepukhin, Pavel A.

AU - Kravchenko, Marionella A.

AU - Skornyakov, Sergey N.

AU - Rusinov, Gennady L.

AU - Chupakhin, Oleg N.

AU - Charushin, Valery N.

PY - 2015/6/5

Y1 - 2015/6/5

KW - Pyrimidine

KW - Antimicobacterial

KW - Tuberculosis

KW - Cross-coupling

KW - Nucleophilic aromatic substitution of hydrogen

KW - MYCOBACTERIUM-TUBERCULOSIS

KW - ANTITUBERCULOSIS ACTIVITY

KW - COUPLING REACTIONS

KW - ARYL BROMIDES

KW - DERIVATIVES

KW - INHIBITORS

KW - ANALOGS

KW - S-N(H)

KW - AGENTS

KW - CHEMOTHERAPY

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UR - https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=tsmetrics&SrcApp=tsm_test&DestApp=WOS_CPL&DestLinkType=FullRecord&KeyUT=000356734600020

U2 - 10.1016/j.ejmech.2015.05.007

DO - 10.1016/j.ejmech.2015.05.007

M3 - Article

VL - 97

SP - 225

EP - 234

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

SN - 0223-5234

ER -