Synthesis, X-ray crystal structure and antimycobacterial activity of enantiomerically pure 1-ethyl-2,3-dicyano-5-(het)aryl-6-hetaryl-1,6-dihydropyrazines

Egor V. Verbitskiy, Maria S. Toporova, Mikhail I. Kodess, Marina A. Ezhikova, Maksim L. Isenov, Marina G. Pervova, Marionella A. Kravchenko, Igor D. Medvinskiy, Sergey N. Skornyakov, Gennady L. Rusinov, Valery N. Charushin

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)
Original languageEnglish
Pages (from-to)247-270
Number of pages24
JournalArkivoc
Volume2014
Issue number5
DOIs
Publication statusPublished - 2014

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Enantiomers
Crystal structure
X rays
Pharmaceutical Preparations
Boronic Acids
Methylene Chloride
X ray analysis
Carboxylic acids
Salts
Derivatives
Acids
Temperature

Keywords

  • Pyrazines
  • Petasis reaction
  • antituberculosis activity
  • extensively drug-resistant and multi-drug-resistant tuberculosis
  • PETASIS REACTION
  • BORONIC ACIDS
  • C-NUCLEOPHILES
  • 1-ETHYL-1,4-DIAZINIUM SALTS
  • ORGANOBORONIC ACIDS
  • PRACTICAL SYNTHESIS
  • MANNICH REACTION
  • O-NUCLEOPHILES
  • SIGMA(H)-ADDUCTS
  • TUBERCULOSIS

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Verbitskiy, Egor V. ; Toporova, Maria S. ; Kodess, Mikhail I. ; Ezhikova, Marina A. ; Isenov, Maksim L. ; Pervova, Marina G. ; Kravchenko, Marionella A. ; Medvinskiy, Igor D. ; Skornyakov, Sergey N. ; Rusinov, Gennady L. ; Charushin, Valery N. / Synthesis, X-ray crystal structure and antimycobacterial activity of enantiomerically pure 1-ethyl-2,3-dicyano-5-(het)aryl-6-hetaryl-1,6-dihydropyrazines. In: Arkivoc. 2014 ; Vol. 2014, No. 5. pp. 247-270.
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keywords = "Pyrazines, Petasis reaction, antituberculosis activity, extensively drug-resistant and multi-drug-resistant tuberculosis, PETASIS REACTION, BORONIC ACIDS, C-NUCLEOPHILES, 1-ETHYL-1,4-DIAZINIUM SALTS, ORGANOBORONIC ACIDS, PRACTICAL SYNTHESIS, MANNICH REACTION, O-NUCLEOPHILES, SIGMA(H)-ADDUCTS, TUBERCULOSIS",
author = "Verbitskiy, {Egor V.} and Toporova, {Maria S.} and Kodess, {Mikhail I.} and Ezhikova, {Marina A.} and Isenov, {Maksim L.} and Pervova, {Marina G.} and Kravchenko, {Marionella A.} and Medvinskiy, {Igor D.} and Skornyakov, {Sergey N.} and Rusinov, {Gennady L.} and Charushin, {Valery N.}",
year = "2014",
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language = "English",
volume = "2014",
pages = "247--270",
journal = "Arkivoc",
issn = "1551-7004",
publisher = "ARKAT USA, Inc.",
number = "5",

}

Synthesis, X-ray crystal structure and antimycobacterial activity of enantiomerically pure 1-ethyl-2,3-dicyano-5-(het)aryl-6-hetaryl-1,6-dihydropyrazines. / Verbitskiy, Egor V.; Toporova, Maria S.; Kodess, Mikhail I.; Ezhikova, Marina A.; Isenov, Maksim L.; Pervova, Marina G.; Kravchenko, Marionella A.; Medvinskiy, Igor D.; Skornyakov, Sergey N.; Rusinov, Gennady L.; Charushin, Valery N.

In: Arkivoc, Vol. 2014, No. 5, 2014, p. 247-270.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Synthesis, X-ray crystal structure and antimycobacterial activity of enantiomerically pure 1-ethyl-2,3-dicyano-5-(het)aryl-6-hetaryl-1,6-dihydropyrazines

AU - Verbitskiy, Egor V.

AU - Toporova, Maria S.

AU - Kodess, Mikhail I.

AU - Ezhikova, Marina A.

AU - Isenov, Maksim L.

AU - Pervova, Marina G.

AU - Kravchenko, Marionella A.

AU - Medvinskiy, Igor D.

AU - Skornyakov, Sergey N.

AU - Rusinov, Gennady L.

AU - Charushin, Valery N.

PY - 2014

Y1 - 2014

KW - Pyrazines

KW - Petasis reaction

KW - antituberculosis activity

KW - extensively drug-resistant and multi-drug-resistant tuberculosis

KW - PETASIS REACTION

KW - BORONIC ACIDS

KW - C-NUCLEOPHILES

KW - 1-ETHYL-1,4-DIAZINIUM SALTS

KW - ORGANOBORONIC ACIDS

KW - PRACTICAL SYNTHESIS

KW - MANNICH REACTION

KW - O-NUCLEOPHILES

KW - SIGMA(H)-ADDUCTS

KW - TUBERCULOSIS

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U2 - 10.3998/ark.5550190.p008.690

DO - 10.3998/ark.5550190.p008.690

M3 - Article

VL - 2014

SP - 247

EP - 270

JO - Arkivoc

JF - Arkivoc

SN - 1551-7004

IS - 5

ER -