ВЗАИМОСВЯЗЬ ЭВОЛЮЦИИ ИММУНИТЕТА И ВОСПАЛЕНИЯ У ПОЗВОНОЧНЫХ

The sequence of developmental stages in the immune system and inflammation in vertebrates is reflected. These stages are the following: the formation of classical forms of adaptive immunity and inflammation for vertebral forms; the origin of cytotoxic T-lymphocytes and T-cell-dependent variants of productive inflammation in fish; the appearance of new antibody classes in tetrapods, and the origin of exudative-destructive inflammation in higher vertebrates and suppurative inflammation in mammals. Each evolutionary stage in the development of immunity and inflammation was determined by the need the organization of the immune system to conform the level of the general organization of vertebrate species. At the same time, each stage predetermined the appearance of “windows of vulnerability” as the possible development of autoimmune, allergic diseases, and systemic complications of the inflammatory process.