Влияние динамики внутриклеточного кальция на электрическую активность клеток синоатриального узла

Resultado de la investigación: Article

Resumen

The influence of intracellular calcium dynamics on spontaneous activity of pacemaker cells was investigated via mathematical modeling. We compared the responses to the inhibition of calcium L-type current in several models of electrical activity of sinoatrial node cells. All models showed a decrease in the maximum velocity of depolarization, action potential amplitude, action potential duration. Calcium clock models showed an increase in the period of calcium oscillation up to 12%. Models in which spontaneous activity is mainly determined by the hyperpolarization-activated current showed up to 15% reduction in the oscillation period. A comparison of theoretical results with experimental data indicates different contribution of intracellular mechanisms to spontaneous activity of pacemaker cells from center and periphery of the sinoatrial node.
Título traducido de la contribuciónInfluence of Intracellular Calcium Dynamics on Electrical Activity of Sinoatrial Node Cells
Idioma originalRussian
Páginas (desde-hasta)906-915
Número de páginas10
PublicaciónBiophysics
Volumen61
N.º5
EstadoPublished - 2016

Level of Research Output

  • VAK List

Huella

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