ИССЛЕДОВАНИЕ ВЛИЯНИЯ ПОСТИНФАРКТНОГО РУБЦА НА ДИНАМИКУ СПИРАЛЬНЫХ ВОЛН В МОДЕЛЯХ ЛЕВОГО ЖЕЛУДОЧКА СЕРДЦА ЧЕЛОВЕКА

Resultado de la investigación: Articlerevisión exhaustiva

Resumen

Spiral or scroll waves of electrical excitation in the myocardium can cause cardiac arrhythmias. It is known that the structural and functional heterogeneity of myocardial tissue is one of the key factors affecting the drift of the scroll waves. In this paper, we studied the dynamics of scroll waves in realistic anatomical models of the left ventricle (LV) of a human heart depending on the geometry of the LV and the depth of the postinfarction scar in the LV wall. Based on ultrasound data, we built two models of LV geometry with averaged parameters observed for normal heart and for the heart of patients with dilated cardiomyopathy. In both models, we formed postinfarction scars of various sizes and varied the transmural depth of the scar in the LV wall. In the absence of myocardial infarction, scroll waves were stable and independent of the LV geometry. In LV models with postinfarction scar, the geometry of the LV influenced the dynamics of the scroll waves. In case of normal geometry, the scroll waves disappeared with a depth of 2/3 or fully transmural scar. In the LV model with dilated cardiomyopathy geometry, at all depths of the scar, a scroll wave break-up (LV fibrillation) was observed after 10-15 seconds of the simulation.
Título traducido de la contribuciónInvestigation of the effect of postinfarction scaron the dynamics of scroll waves in modelsof the human heart left ventricle
Idioma originalRussian
Páginas (desde-hasta)57-61
Número de páginas5
PublicaciónДневник Казанской медицинской школы
N.º1(23)
EstadoPublished - 2019

GRNTI

  • 76.00.00 MEDICINE AND HEALTH CARE

Level of Research Output

  • VAK List

Huella

Profundice en los temas de investigación de 'ИССЛЕДОВАНИЕ ВЛИЯНИЯ ПОСТИНФАРКТНОГО РУБЦА НА ДИНАМИКУ СПИРАЛЬНЫХ ВОЛН В МОДЕЛЯХ ЛЕВОГО ЖЕЛУДОЧКА СЕРДЦА ЧЕЛОВЕКА'. En conjunto forman una huella única.

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