ЭКСПЕРИМЕНТАЛЬНОЕ ИЗУЧЕНИЕ КАРДИОТОКСИЧЕСКОГО ДЕЙСТВИЯ НАНОЧАСТИЦ ОКСИДА СВИНЦА ПРИ РАЗНЫХ ПУТЯХ ПОСТУПЛЕНИЯ В ОРГАНИЗМ

И. А. Минигалиева, М. П. Сутункова, Светлана Владиславовна Клинова, С. Н. Соловьева, Л. И. Привалова, Владимир Борисович Гурвич, Иван Николаевич Чернышов, Ю. В. Рябова, Т. В. Бушуева, Владимир Яковлевич Шур, Екатерина Владимировна Шишкина, Б. А. Кацнельсон

Resultado de la investigación: Article

Resumen

Background: Lead oxide nanoparticles are emitted in the workplace air of copper smelters. They are also a by-product in many other metallurgical industries. Objectives: Adverse health effects of lead oxide nanoparticles (PbO-NPs) were assessed in vivo using various routes of exposure with special attention paid to particle cardiotoxicity. Materials and methods: The subacute inhalation experiments were conducted on outbred female rats exposed to the generated aerosol of PbO-NPs in the concentration of 1.30 ± 0.10 mg/m3, 4 hours a day during five consecutive days, using the Nose-Only Inhalation Exposure System. The study of subchronic exposure to PbO-NPs was conducted on male rats using intraperitoneal injections made thrice a week during six weeks (18 injections in total). Conclusions: Following both types of exposure to PbO-NPs, we observed changes in toxicological indices including those specific for lead including a decrease in hemoglobin counts, an increase in blood reticulocyte counts and urine concentrations of δ-aminolevulenic acid. The subacute inhalation exposure to PbO-NPs affected electrocardiographic findings in animals (an increase in amplitudes of P and T waves) while the subchronic intraperitoneal injections decreased blood pressure and changed biochemical indices of the cardiovascular system (decreased activity of the angiotensin-converting enzyme and the concentration of endodelin-1).
Título traducido de la contribuciónTHE EXPERIMENTAL STUDY OF CARDIOTOXIC EFFECTS OF LEAD OXIDE NANOPARTICLES BY THEIR VARIOUS ROUTES OF EXPOSURE
Idioma originalRussian
Páginas (desde-hasta)67-72
Número de páginas6
PublicaciónЗдоровье населения и среда обитания
N.º9 (330)
DOI
EstadoPublished - 2020

GRNTI

  • 76.00.00 MEDICINE AND HEALTH CARE

Level of Research Output

  • VAK List

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