Synthesis of 5-(het)aryl- and 4,5-di(het)ary1-2-(thio)morpholinopyrimidines from 2-chloropyrimidine via S-N(H) and cross-coupling reactions

E. M. Cheprakova, E. V. Verbitskiy, M. A. Ezhikova, M. I. Kodess, M. G. Pervova, P. A. Slepukhin, M. S. Toporova, M. A. Kravchenko, I. D. Medvinskiy, G. L. Rusinov, V. N. Charushin

Resultado de la investigación: Articlerevisión exhaustiva

9 Citas (Scopus)

Resumen

It has been shown that various combinations of nucleophilic aromatic substitution of hydrogen (S-N(H)), S-N(ipso) and the microwave-assisted Suzuki cross-coupling reactions are a versatile method for the synthesis of 5-(het)ary1-2-(thio)morpholinopyrimidine and 4,5-di(het)ary1-2(thio)morpholinopyrimidine derivatives. All synthesized pyrimidines were found to be active in micromolar concentrations in vitro against Mycobacterium tuberculosis H(37)Rv.
Idioma originalEnglish
Páginas (desde-hasta)1350-1358
Número de páginas9
PublicaciónRussian Chemical Bulletin
Volumen63
N.º6
DOI
EstadoPublished - 1 ene. 2014

ASJC Scopus subject areas

  • Chemistry(all)

WoS ResearchAreas Categories

  • Chemistry, Multidisciplinary

Huella

Profundice en los temas de investigación de 'Synthesis of 5-(het)aryl- and 4,5-di(het)ary1-2-(thio)morpholinopyrimidines from 2-chloropyrimidine via S-N(H) and cross-coupling reactions'. En conjunto forman una huella única.

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