КОНСЕНСУСНЫЙ ПРОГНОЗ, НАПРАВЛЕННЫЙ СИНТЕЗ И ОПРЕДЕЛЕНИЕ АНТИГЛИКИРУЮЩЕЙ И АНТИАГРЕГАНТНОЙ АКТИВНОСТЕЙ 3,6-ДИЗАМЕЩЕННЫХ 1,2,4,5-ТЕТРАЗИНОВ

Р. И. Ишметова, Д. А. Бабков, А. Ф. Кучерявенок, В. А. Бабкова, В. С. Сиротенко, Н. К. Игнатенко, С. Г. Толщина, П. М. Васильев, Г. Л. Русинов, А. А. Спасов

Resultado de pesquisa: Article

Resumo

According to the in silico consensus activity prediction, a series of 3,6-disubstituted 1,2,4,5-tetrazines were synthesized as promising inhibitors of the Maillard reaction. In addition to the studies of antiglycation activity, a comparative in vitro evaluation of the effect of the synthesized compounds on the ADP-induced rabbit platelet aggregation model was carried out. Compounds with antiglycation and antiplatelet activities significantly higher than that of the reference drugs, aminoguanidine and acetylsalicylic acid, were revealed.

Título traduzido da contribuiçãoIn silico consensus activity prediction, rational synthesis, and evaluation of antiglycation and antiplatelet activities of 3,6-disubstituted 1,2,4,5-tetrazines
Idioma originalRussian
Páginas (de-até)768-773
Número de páginas6
RevistaИзвестия Академии наук. Серия химическая
Estado da publicaçãoPublished - 2020

GRNTI

  • 31.00.00 CHEMISTRY

Level of Research Output

  • VAK List

Impressão digital Mergulhe nos tópicos de investigação de “КОНСЕНСУСНЫЙ ПРОГНОЗ, НАПРАВЛЕННЫЙ СИНТЕЗ И ОПРЕДЕЛЕНИЕ АНТИГЛИКИРУЮЩЕЙ И АНТИАГРЕГАНТНОЙ АКТИВНОСТЕЙ 3,6-ДИЗАМЕЩЕННЫХ 1,2,4,5-ТЕТРАЗИНОВ“. Em conjunto formam uma impressão digital única.

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