КОНСЕНСУСНЫЙ ПРОГНОЗ, НАПРАВЛЕННЫЙ СИНТЕЗ И ОПРЕДЕЛЕНИЕ АНТИГЛИКИРУЮЩЕЙ И АНТИАГРЕГАНТНОЙ АКТИВНОСТЕЙ 3,6-ДИЗАМЕЩЕННЫХ 1,2,4,5-ТЕТРАЗИНОВ

Р. И. Ишметова, Д. А. Бабков, А. Ф. Кучерявенок, В. А. Бабкова, В. С. Сиротенко, Н. К. Игнатенко, С. Г. Толщина, П. М. Васильев, Г. Л. Русинов, А. А. Спасов

科研成果: Article

摘要

According to the in silico consensus activity prediction, a series of 3,6-disubstituted 1,2,4,5-tetrazines were synthesized as promising inhibitors of the Maillard reaction. In addition to the studies of antiglycation activity, a comparative in vitro evaluation of the effect of the synthesized compounds on the ADP-induced rabbit platelet aggregation model was carried out. Compounds with antiglycation and antiplatelet activities significantly higher than that of the reference drugs, aminoguanidine and acetylsalicylic acid, were revealed.

投稿的翻译标题In silico consensus activity prediction, rational synthesis, and evaluation of antiglycation and antiplatelet activities of 3,6-disubstituted 1,2,4,5-tetrazines
源语言Russian
页(从-至)768-773
页数6
期刊Известия Академии наук. Серия химическая
Published - 2020

GRNTI

  • 31.00.00 CHEMISTRY

Level of Research Output

  • VAK List

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