@article{1ade6d20a2dd4a0289ae543e721e8b5e,
title = "Synthesis of 5-(het)aryl- and 4,5-di(het)ary1-2-(thio)morpholinopyrimidines from 2-chloropyrimidine via S-N(H) and cross-coupling reactions",
abstract = "It has been shown that various combinations of nucleophilic aromatic substitution of hydrogen (S-N(H)), S-N(ipso) and the microwave-assisted Suzuki cross-coupling reactions are a versatile method for the synthesis of 5-(het)ary1-2-(thio)morpholinopyrimidine and 4,5-di(het)ary1-2(thio)morpholinopyrimidine derivatives. All synthesized pyrimidines were found to be active in micromolar concentrations in vitro against Mycobacterium tuberculosis H(37)Rv.",
keywords = "antituberculosis activity, cross-coupling, microwave irradiation, morpholine, nucleophilic aromatic substitution of hydrogen, pyrimidines, thiomorpholine",
author = "Cheprakova, {E. M.} and Verbitskiy, {E. V.} and Ezhikova, {M. A.} and Kodess, {M. I.} and Pervova, {M. G.} and Slepukhin, {P. A.} and Toporova, {M. S.} and Kravchenko, {M. A.} and Medvinskiy, {I. D.} and Rusinov, {G. L.} and Charushin, {V. N.}",
year = "2014",
month = jan,
day = "1",
doi = "10.1007/s11172-014-0602-y",
language = "English",
volume = "63",
pages = "1350--1358",
journal = "Russian Chemical Bulletin",
issn = "1066-5285",
publisher = "Springer",
number = "6",
}